The specific assessment process for the management of intractable hypertension is as follows: 1. Is the treatment plan appropriate? 2. Are there any drug interfering effects? 3. Is the patient compliant with the treatment? 4, Are there any adverse factors in life behavior that affect the antihypertensive effect? 5.Is there pseudohypertension or white coat hypertension? 6.Is there volume overload? 7, Is secondary hypertension ruled out? By carefully assessing the above questions, 80% of patients with recalcitrant hypertension will be able to find the cause and correct it. If blood pressure remains uncontrolled, further hemodynamic and neurohormonal testing should be performed to look for possible mechanisms causing treatment resistance. These mechanisms may be the primary cause of recalcitrant hypertension or may be a compensatory response to long-term treatment. The combination therapy regimen is adjusted more specifically according to the possible mechanisms. Increased cardiac output: receptor blockers or non-dihydropyridine calcium antagonists; elevated peripheral vascular resistance: dihydropyridine calcium antagonists, angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists; elevated plasma renin activity: angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists; elevated plasma or urinary aldosterone: ambrisentin. If all approaches fail, then discontinuing medication for a short time, monitoring blood pressure closely, and restarting a new regimen may help break the vicious cycle of elevated blood pressure.