In the long-term or large dose of hormone use may bring sequelae to the body, such as glucose metabolism disorders, high blood pressure, leading to osteoporosis and femoral head necrosis, reduce body resistance, stress ulcers, etc., therefore, hormone shock treatment needs to be under the guidance of the doctor to strictly grasp the indications. 1. Glucose metabolism disorder: hormone can cause glucose metabolism disorder or even steroid diabetes, so that the blood sugar increases. 2. Hypertension: glucocorticoids have the effect of sodium and water retention, long-term use or large doses, may lead to obesity, and then cause blood pressure. 3. Osteoporosis and necrosis of the femoral head: the application of large doses of hormones will cause a serious loss of calcium, which can easily cause necrosis of the femoral head osteoporosis. 4. Decrease in resistance: long-term use of hormones will make the body’s own adrenal cortex function decreases, so that the body’s resistance or immunity to decline. 5. Stress ulcers: hormone shock therapy may lead to stress ulcers, and in severe cases, may even cause gastrointestinal bleeding. Therefore, hormone is a double-edged sword, need to strictly grasp the indications of hormone shock therapy under the guidance of doctors.