Mean hemoglobin count is the average amount of hemoglobin contained in each red blood cell. It is not possible to make a clinical diagnosis based on a single value of high mean hemoglobin, but needs to be combined with other test results to make a definitive diagnosis, mostly related to megaloblastic anemia, aplastic anemia and hypothyroidism. Some patients with high mean hemoglobin may also have low water intake or loss of body fluids, such as vomiting and profuse sweating, which can be restored by rechecking the blood picture after the body fluids are balanced. 1. megaloblastic anemia: If folic acid and vitamin B12 are below the normal range, megaloblastic anemia is generally considered to be caused by folic acid or vitamin B12 deficiency or long-term use of certain drugs. The anemia is caused by deficiency of folic acid or vitamin B12 or long-term use of certain drugs. The prognosis is generally good if the primary disease is actively treated and folic acid or vitamin B12 is supplemented with medication to replenish the nutrients lacking in the body; at the same time, the poor eating habits of partial and picky eating are corrected and fresh fruits and vegetables are eaten more often. For patients with pernicious anemia, lifelong treatment with vitamin B12 is required. 2. Aplastic anemia: When the average red blood cell hemoglobin amount is high accompanied by abnormalities such as decreased red blood cells and increased lymphocyte ratio, and accompanied by decreased hematopoietic cells, it may be aplastic anemia. Clinical treatment requires correction of anemia, prevention of infection, and avoidance of bleeding due to trauma, followed by targeted immunosuppressive therapy and hematopoietic therapy, and also hematopoietic stem cell transplantation; 3. FT4 is decreased, which may suggest hypothyroidism. Clinical treatment is usually based on levothyroxine therapy. In addition, if there is an increase in red blood cells and hemoglobin, serum tests may also indicate excessive blood bilirubin production, which can be seen in erythrocytosis and may be due to heart disease, kidney disease, burns, severe diarrhea, etc.