Syphilis manifestations are diverse, generally can not be diagnosed by self-testing, the current diagnosis is mainly based on medical history, physical examination and laboratory tests to clarify, it is recommended to consult a specialist. 1. Medical history: there is a history of obvious contact with syphilis patients, such as sexual contact and blood contact. 2. Physical examination: Stage 1 syphilis may present with chancre and lymphadenitis; stage 2 syphilis may present with skin and mucous membrane injuries, such as syphilitic rash, flat warts, syphilitic alopecia, etc., and may present with multiple injuries such as bone and joint damages, eye damages, etc.; and stage 3 syphilis may present with cardiovascular syphilis and neurosyphilis. 3. Laboratory examination: the main examination method and the main basis for diagnosis is the syphilis serological test, and if necessary, it is feasible to conduct several examinations to make it clear, patients with hard chancre and flat warts can adopt the syphilis spirochete test, the cerebrospinal fluid examination can diagnose neurosyphilis, and the X-ray, ultrasound, CT or MRI can help to diagnose the osteoarticular syphilis, cardiovascular syphilis and neurosyphilis. If you suspect syphilis, you need to consult a doctor in time and use regular methods of testing, not self-testing, so as not to delay the condition.