Clinically, there does not exist the saying that nine signals indicate that cancer has reached the late stage. Patients in the late stage of cancer may have fever, body pain, bleeding, organ obstruction, malignant disease and so on. 1. Fever: patients in the late stage of cancer may have increased metabolism and necrotic material due to larger tumor and more serious condition. It may lead to the increase of body temperature, which is about 38.5℃, and irregular and continuous low fever. 2. Body pain: with the growth of tumor or rupture and infection, etc., it will lead to the peripheral nerves and nerve trunks being stimulated and compressed, and there will be different degrees of body pain in the late stage of cancer. At the beginning, it is mostly hidden pain or dull pain, and with the development of the disease, the pain will gradually worsen. 3. Bleeding: In the late stage of cancer, due to the rupture of blood vessels caused by the invasion of cancer cells into blood vessels, there will be bleeding. For example, coughing up blood may appear in the late stage of lung cancer, cervical cancer may have vaginal bleeding and so on. 4. Organ obstruction: due to the rapid growth of cancer cells, it may affect other organs and cause obstruction; if the cancer occurs in the respiratory tract in the late stage, it will lead to difficulty in breathing. 5. Malignant disease: manifested by extreme emaciation, skin and bones, like skeleton, anemia, weakness, complete bed-ridden, unable to take care of oneself, extreme pain, general exhaustion and other syndromes. Different cancers will have different symptoms in the late stage, and it is recommended that patients actively cooperate with doctors to reduce pain and improve the quality of life.