Amlodipine is a calcium antagonist, for example, the most common and earliest generation of antihypertensive drug nifedipine is a calcium antagonist, amlodipine is the third generation, including the current Loxodipine is the third generation of very long-acting calcium antagonist. The mechanism of action of calcium antagonists is completely different from that of irbesartan. Calcium antagonists lower blood pressure by inhibiting cellular calcium channels, dilating peripheral arterial vessels, and improving blood flow, especially in patients with hypertension and coronary artery disease. Amlodipine itself also has an indication for the treatment of angina pectoris, so amlodipine and Irbesartan are actually different classes of antihypertensive drugs. If Irbesartan does not control blood pressure, it may be combined with antihypertensive drugs. The combination of antihypertensive drugs will also be based on principles, for example, Irbesartan combined with Amlodipine is not effective may also add diuretics. If blood pressure is still not controlled, such as in cases of intractable hypertension, a beta-blocker may be added. Irbesartan is mainly used for hypertension with diabetes, while amlodipine is more suitable for hypertension with heart failure and coronary artery disease.