Irregular mass shadow seen in the duodenal jugular region may be caused by pancreatic cystic disease, pancreatic cancer and peri jugular cancer. Generally, surgery is often adopted, and chemotherapy and other treatments are combined with specific conditions. 1. Pancreatic cystic disease: including pancreatic pseudocyst, pancreatic cystic tumor and so on. Surgical treatment is usually carried out. Surgical methods for pancreatic pseudocysts include internal drainage, external drainage, surgical resection of pancreatic pseudocysts, etc. Pancreatic cystic tumors include plasma adenoma, mucinous cystic adenoma, intraductal papillary mucinous neoplasm, and solid pseudopapillary neoplasm, all of which need surgical treatment. 2. Pancreatic cancer: usually perform pancreatic head duodenectomy. At the same time, the corresponding lymph node areas need to be cleared. For unresectable pancreatic cancer, radiotherapy, chemotherapy and immunotherapy can be used as comprehensive treatment means, and commonly used drugs include gemcitabine, 5-fluorouracil and so on. 3. Peripancreatic cancer: generally use pancreatic head duodenectomy, with better long-term effect. For individuals of advanced age, who have developed liver metastasis and the tumor cannot be resected, palliative surgery, such as biliary-intestinal anastomosis, gastrojejunal anastomosis, etc., can be performed. They are also treated with chemotherapy (e.g., mitomycin, vincristine, etc.). If there is an irregular mass in the duodenal jugular region, seek medical attention as soon as possible. Do not self-medicate to avoid serious complications.