There are usually no specific 8 signs before the death of bile duct cancer patients. In the late stage of bile duct cancer, the tumor may grow gradually with the progress of the disease, which may harm the surrounding tissues and organs, break down, bleeding, and even metastasis and liver and kidney failure, and may often show wasting, slowed heart rate, decreased blood pressure, severe anemia, ascites and other manifestations before the death. Bile duct cancer is a common malignant tumor in biliary system with high malignancy and poor prognosis. Bile duct cancer starts insidiously, lacks typical clinical symptoms and signs, and lacks effective screening means. As the tumor continues to progress, patients may show jaundice symptoms such as yellow staining of skin and sclera, wasting, arrhythmia, slowed heart rate, as well as gastrointestinal manifestations such as nausea and vomiting, and even severe anemia and ascites before death. Patients with bile duct cancer may have severe ascites before death, which may easily compress the chest cavity and affect breathing, and may have difficulty in breathing; they may have biliary bleeding and black stool and positive fecal occult blood test when the tumor ruptures; they may have severe abdominal pain in the right upper abdomen before death, which is unbearable, and if it spreads to bone, pathological fracture may occur in serious cases; patients with cerebral bridge hemorrhage may even have coma, loud breathing and slow heart rate, etc. In general, the patient will have an obvious state of failure before the end of life, and may show manifestations such as a significant decrease in heart rate or slowed breathing, or even dilated pupils, loss of physiological reflexes or even a decrease in blood pressure. If a patient with various signs is weak, family members can accompany the patient appropriately for end-of-life care according to the medical care arrangement.