Patients should not urinate or get up until at least one hour after vaginal insertion of interferon. If they urinate prematurely after insertion, standing or moving, the drug may be excreted quickly under the effect of gravity or increased abdominal pressure. It is recommended that patients must choose to use it before bedtime, and empty the urine and stool before use, try to drink less water, do not get up for a short time, if the patient has to go to the toilet within an hour of the plug, then try to choose a bidet, do not choose a squat toilet, can reduce the role of abdominal pressure, reduce the chances of drug discharge. If the drug is discharged within an hour of the plug due to premature activity, most of the drug is not absorbed and does not play a therapeutic role, you need to plug another pill.