The methods of treating gastric cancer include surgery to remove the diseased part of stomach, conservative treatment such as radiotherapy, what are the commonly used chemotherapeutic drugs in clinic? Commonly used chemotherapeutic drugs: 1. Fluorouracil (5-Fu): since 1958, it has become the first choice and basic drug for the treatment of gastric cancer both at home and abroad. 5-Fu is a cell-cycle specific drug, which transforms into 5-fluoro-2′-deoxyuridine monophosphate in vivo, and the latter inhibits the thymine nucleotide synthetase, prevents the transformation of uracil deoxyribonucleotide into thymine deoxyribonucleotide, and affects the biosynthesis of cellular DNA, thus leading to cell damage and death. cellular DNA biosynthesis, thus leading to cell damage and death. The total effective rate is about 20%, and the effective period is short, usually averaging 4 to 5 months. The drug can be applied intravenously or taken orally. 2, Tegafur (furan fluorouracil): for the 1966 synthesis of fluorouracil (5-Fu) derivatives, in vivo by the liver’s cytochrome p-450 microsomal enzymes and local tissues of soluble enzymes converted to 5-Fu and play a role. Due to the low toxicity of the drug, which is 6 times smaller than 5-Fu, the chemotherapeutic index is 2 times of fluorouracil (5-Fu), and the oral and rectal administration of the drug is well absorbed, thus it has become a commonly used drug for the treatment of gastric cancer in recent years. The total effective rate of treating gastric cancer is 31%. 3. Mitomycin (MMC): It is a cell cycle non-specific drug containing alkylating group successfully developed by Japan in 1955 and China in 1965. Its effect is similar to that of alkylating agent, which can cross-link with DNA and depolymerize DNA, thus affecting the DNA replication of proliferating cells. The overall effectiveness rate is about 10% to 15%, and the response period is short, averaging about 2 months. The drug is usually administered intravenously in large interstitial doses of 4 to 10 mg per dose, twice weekly. Because of the drug’s greater toxic response to the blood system and shorter remission period, it is often applied in the combination drug (MFC) program. 4.Simustine(methylcyclohexylnitrosourea)：it is a nitrosourea alkylating agent, which is a broad-spectrum non-specific drug of cell cycle, and it has certain curative effect on gastric cancer, with the effective rate of 10%～20%, and the validity period is about 2～3 months. 5.Doxorubicin (Adriamycin): it is anthracycline antitumor antibiotic, belongs to cell cycle non-specific drugs, and has been used clinically for more than twenty years, inducing rapid remission, but the duration is not long, with the total effective rate of 21%~31%. This product has strong toxicity to the heart. 6, cisplatin (CCDP): this product as a new type of inorganic anticancer platinum compounds in the early 1970s began to be used in the clinic, the study shows that this product and a variety of anticancer drugs have synergistic effect, and there is no obvious cross-resistance, so it is widely used in the combination of chemotherapy. 7, etoposide (onychoside): is more than 40 kinds of commonly used chemotherapeutic drugs in the popular and younger varieties, belongs to the cell cycle-specific drugs, the role of the end of the S phase, the mechanism is to cut off the topoisomerase binding of the DNA double-stranded, and can impede the nucleoside through the plasma membrane, so that it can not enter the nucleus to participate in the replication of DNA. Literature reports that the effective rate of single use for middle and advanced gastric cancer is 21%, and the effective rate of combined chemotherapy can reach 60%～70%, and the complete remission rate can reach 20%. The above are the commonly used chemotherapeutic drugs in clinical guide, if you want to know more about stomach cancer, please log in the oncology of Seek Medical Help Community.