The prevention of monkeypox disease is mainly to avoid contact with infectious sources, cut off the transmission channels, and protect susceptible people. Monkeypox is a viral disease caused by monkeypox virus infection, the main clinical manifestations are fever, rash, lymph node swelling. 1. Avoid contact with infectious source: the main infectious source of monkeypox virus is rodents infected with monkeypox virus, in addition, primates such as monkeys, humans and other infected can also be called infectious source, we need to avoid contact with animals infected with monkeypox virus in daily life. 2. Cut off the transmission pathway: Monkeypox virus usually invades the human body through mucous membranes and broken skin, and it is mainly infected through contact with blood and body fluids of the infected animal lesions, or by bites and scratches. Transmission between groups of people mainly through close contact, but also through droplet transmission, but also through the placenta vertical transmission. It is necessary to cut off the means of transmission, such as not contacting infected animals and people. 3. 3. Protection of susceptible groups: there is no vaccine for monkeypox virus, and those who have been vaccinated against smallpox have a certain degree of cross-protection against monkeypox virus. If found infected with monkeypox disease, it is necessary to follow the doctor’s advice and standardize the treatment in time to avoid adverse consequences.