With the increasing trend of tumor incidence year by year, people around and patients coming to the clinic are showing great psychological panic about tumors, and increasingly intensive medical checkups include tumor markers as a regular guest in the medical checkup list. It is widely believed that it can help detect tumors as early as possible and improve the cure rate. However, we need to have a correct understanding of tumor markers, if we blindly abuse them, it will only bring mental burden and waste of resources. First of all, let us know about tumor markers, which refer to a class of substances that are synthesized or released by tumor cells themselves or produced by the body in response to tumor cells during the process of tumorigenesis and proliferation to mark the existence and growth of tumor, mainly including proteins, hormones, enzymes, polyamines, oncogene products and so on. These substances are not present in normal adults or are present at significantly higher levels in cancer patients than in normal subjects. Regarding the specificity of tumor markers, many experts say that a single tumor marker result cannot be used as a basis for tumor diagnosis at all. Seventy percent of people with elevated AFP end up with test results that show they do not have liver cancer. The results of tumor markers are uncertain and are generally used for testing after tumor detection. There are only a few specific indicators that can really reflect cancerous changes. More noteworthy is that non-tumor diseases can also cause elevated markers, such as chronic hepatitis, prostate enlargement, endometriosis, or the use of certain medications, and even the technical standards and stability of the laboratory may interfere with the test results. Therefore, it is possible for many healthy people to get false positive test results. For tumor markers, an objective and reasonable view is as follows: 1. Tumor markers are not suitable for screening of tumors in healthy people. 2. High-risk groups should be tested. For high-risk groups of cancer that really need to be screened, tumor screening can indeed play a role in early detection and diagnosis. Such groups include those with family history of malignant tumor (immediate or collateral relatives within three generations); those with bad habits (long-term heavy smoking and alcoholism, overwork, serious partial eating, etc.); occupational factors (such as long-term exposure to toxic and harmful substances); living environment pollution (chemical, heavy metal, nuclear pollution, etc.); microbial infections (hepatitis B virus, HIV, human papilloma virus, Helicobacter infection, etc.). . 3, tumor screening is important but should be targeted. 4. If there is any abnormality, don’t be overly nervous or panic. It is only a possible hint or signal. Doctors should do further examination according to the individual’s specific situation, combined with the information of imaging data and physical target, to do comprehensive analysis. 5. In addition to screening, it is actually crucial to prevent cancer from lifestyle, and efforts should be made to achieve a balanced diet, ensure sleep, regular exercise and a good attitude, etc.