With the continuous development and advancement of medicine, the treatment of tumor has diversified, from the original surgery, radiotherapy and chemotherapy to the current multidisciplinary comprehensive treatment of surgery, radiotherapy, chemotherapy, targeted therapy, minimally invasive therapy, endocrine therapy, interventional therapy, biological immunotherapy and Chinese medicine therapy. There are different treatment methods for different tumors, and each of the above treatment methods has its own advantages. The treatment of tumor has entered the era of comprehensive treatment. Clinical practice proves that it is often difficult to achieve the best effect by any single treatment method at this stage. Therefore, except for some early stage tumors and some special types of tumors, the principle of treatment for most tumors is comprehensive treatment. The concept of multimodality therapy is to apply the existing therapies in a planned and rational way according to the patient’s body condition, pathological type, invasion range (stage) and development trend of tumor, in order to improve the cure rate, prolong the survival period and improve the quality of life of patients. The correct understanding of the concept of comprehensive tumor treatment and its scientific connotation has important clinical practical significance, which will help to formulate a reasonable individualized comprehensive treatment plan for each tumor patient in order to achieve the best treatment effect. Comprehensive tumor treatment is not a simple combination of surgery, chemotherapy, radiotherapy, biological treatment and Chinese medicine treatment, but a planned, step-by-step and sequential collection of individualized treatment, which is a systematic treatment process that requires the effective collaboration of multiple disciplines such as surgery, radiotherapy and chemotherapy to complete successfully. Although the comprehensive treatment plan is not a fixed treatment model, it may be adjusted in the process of diagnosis and treatment with the gradual improvement of diagnosis and the difference of therapeutic effect. There are two types of comprehensive tumor treatment: radical treatment and palliative treatment. Once the tumor is diagnosed, systematic and comprehensive adjuvant examinations should be conducted, and the empirical efficacy and treatment purpose of the tumor should be initially evaluated. If the tumor has the possibility of cure, it should be treated with the purpose of radical treatment, and various effective treatment methods should be used to actively treat the tumor and strive for cure by all means. However, since the treatment of many advanced tumors at this stage is palliative treatment, with the basic goal of prolonging patients’ survival time and improving their quality of life, therefore, when formulating comprehensive treatment plans, we should not only pay attention to patients’ recent efficacy, but also pay more attention to patients’ long-term efficacy and quality of life. However, many tumor patients do not know much about the modern treatment means, and some doctors in the department do not know enough about the modern multidisciplinary treatment, which causes some effective and reasonable treatment cannot be provided to the patients in time and miss the good treatment time. This requires our medical and nursing staff to keep learning new knowledge, not to be stagnant, and to provide patients with the most reasonable treatment based on the principle of giving priority to patients’ interests.