Considering the interaction between target organ microenvironment and tumor cells, the concept of stratified treatment of different metastatic organs in recurrent metastatic breast cancer, specific chemotherapy with doxorubicin combined with cetepe was used for breast cancer liver metastases. It was found that the efficacy of this regimen was 33.9% for localized lesions in the liver, and the efficacy may be related to mutations in SNPs sites of drug-metabolizing enzymes and related pathways such as tumor stem cells, redox, ER, and multidrug resistance. In addition, we also examined the sensitivity of breast cancer stem cells in breast cancer cell lines to commonly used cytotoxic drugs, and selected CD44+/CD24-/lower breast cancer stem cell subpopulations in two breast cancer cell lines, MCF-7 and MDA-MB231, and examined their sensitivity to different concentrations of paclitaxel, adriamycin and cetapide. The results showed that low concentrations of cetapide significantly killed breast cancer stem cells. Spinal metastasis of breast cancer causes limb movement impairment and seriously affects the quality of life of patients. In years of clinical practice, we found that gemcitabine or gemcitabine combined with docetaxel regimen, together with immunotherapy, has been effective in the treatment of spinal metastases from breast cancer. Malignant cavity effusion is one of the common complications in patients with advanced tumors. Large or rapidly growing malignant effusions can cause severe symptoms and affect patients’ quality of life. The median survival of patients with malignant peritoneal effusion is only a few weeks to a few months, and the 1-year survival rate is less than 10%. Malignant body cavity effusion is difficult to treat, and in addition to systemic chemotherapy, local intracavitary infusion chemotherapy, gene therapy and immunotherapy have become new means of effusion treatment. Local treatment for malignant body cavity effusion does not significantly prolong patient survival, but has a significant role in relieving patients’ clinical symptoms.