Duodenal papillary space-occupying changes are the presence of a mass at the duodenal papilla. According to the nature of the swelling can be divided into polyps, benign tumors, mesenchymal tumors, malignant tumors and so on. 1. Polyps: Duodenal papilla polyps may be produced due to genetic factors or prolonged inflammatory stimulation of the intestinal area. Lead to duodenal papilla occupying changes. Appears if there is no obvious discomfort, the polyp is small patients usually do not need treatment. If the polyp is large, there is a tendency to malignancy, the need for timely surgical resection. 2. Benign tumors: such as duodenal cysts, is a benign cystic mass, resulting in the duodenal papilla occupying changes. Patients with small cyst volume and no compression symptoms can be treated conservatively. If the size of the cyst is large, laparoscopic resection is recommended to avoid compression of the intestinal canal causing intestinal obstruction. 3. Mesenchymal tumor: it has a certain tendency of malignant transformation, and may invade, locally infiltrate and metastasize to distant organs, resulting in the duodenal papilla occupying changes. It can be treated by surgical resection or targeted drug therapy. 4. Malignant tumors: malignant tumors grow faster, the border is not clear, easy to spread and metastasis, resulting in duodenal papilla occupying changes. Early diagnosis is clear can be radical surgical resection, the prognosis is better. The disease into the advanced stage can be taken to radiotherapy, prolong the patient’s survival. When the duodenal papilla occupying changes are found, patients need to do pathological biopsy to clarify the nature of the occupying lesion, and choose the appropriate treatment under the guidance of professional doctors.