Panic disorder (PD) is a group of acute anxiety disorders characterized by recurrent palpitations, sweating, tremors, and other vegetative symptoms, accompanied by a strong sense of near-death or loss of control. Several episodes can be followed by anticipatory anxiety, place terror and depressive symptoms. The lifetime prevalence of PD in the United States is around 3%, and is higher in women than in men. The theoretical basis of cognitive behavioral therapy (CBT) is that panic symptoms are caused by patients automatically assigning false meanings to stimuli that are insufficient to cause a violent response, which in turn causes emotional reactions and behavioral changes. Patients themselves often do not recognize their misperceptions, but constantly adopt various ways to alleviate the resulting maladjustment. The essence of treatment is to change the patient’s misperceptions and behavioral reshaping to alleviate panic symptoms. Through interventions at both the cognitive and behavioral levels, patients are better equipped to face social, psychological or physical stressors. The most basic guideline is to help patients break the vicious cycle between anxiety and somatic sensory sensitivity at the cognitive level and desensitize them to the stimuli that cause panic at the behavioral level. 1. Psychoeducation: Explain to the patient the composition and meaning of panic symptoms, and explain to the patient that these symptoms do not serious organic disease. The patient recognizes and names these symptoms well with the help of the therapist and recognizes their positive significance for the organism. Help them to understand the process and purpose of cognitive-behavioral therapy, and also explain to the patient the mechanism of panic disorder through the experiment of active hyperventilation induced panic attack. 2. Monitoring and recording: Ask the patient to continuously record the panic attacks and his or her perception of the process by keeping a diary to help him or her assess the frequency and natural history of panic attacks and to help the counselor further discover the interaction with internal stimuli (mood swings) or external stimuli. 3. Breathing training: Learning deep and slow abdominal breathing, practiced daily, to help the patient control somatic arousal. 4. Cognitive reconstruction: Identification and documentation of worries caused by one’s own hypersensitive sensations. Most of these fears are excessive and unrealistic, while the patient believes that they can cause catastrophic consequences. The counselor discusses these feelings with the patient and asks the patient to think about some objective evidence and other consequences that may occur. The patient is helped to gradually distinguish the initiating organs that cause the panic and the consequent misinterpretation of the hypersensitive sensations of these organs, and eventually achieve cognitive reconstruction. 5. Exposure desensitization: The patient can be exposed step by step, or shock exposure, or “virtual reality” exposure, depending on the patient’s specific situation. 6. Implementation points: Patients are required to actively cooperate and give time for training and recording every day. Patients should actively face the anxiety-producing environment, about 10% of patients are not willing to do so, so it will affect the effectiveness of the treatment.