Primary Lateral Sclerosis is not Acromegaly, both are motor neuron diseases with differences in clinical presentation. Lateral sclerosis, also known as amyotrophic lateral sclerosis, often starts after the age of 40, is a rare progressive, degenerative disease of the motor neurons, which can cause gradual weakness and atrophy of the muscles of the whole body, dysphagia, up to complete paralysis and respiratory muscle paralysis. Primary lateral sclerosis is rarer than acromegaly and tends to start after the age of 50 years, presenting with slowly progressive weakness in both lower or upper limbs or in all four limbs, usually pronounced in the lower limbs. The main clinical manifestations are increased muscle tone, hypertonic tendon reflexes, scissor gait, and a positive pyramidal sign without significant muscle atrophy or fascicular fibrillation. These two diseases are motor neuron disease, there is no good treatment, if you are not feeling well, you should go to the hospital in time to consult a physician for guidance.