High thyroglobulin antibodies may be a sign of autoimmune thyroid disease. Usually, thyroglobulin is the target antigen of thyroglobulin antibodies and belongs to the soluble proteins synthesized and secreted by thyroid epithelial cells. It is a common thyroid autoantibody and is usually present in the serum of patients with autoimmune thyroid disease. When thyroglobulin binds to thyroglobulin antibodies, an immune reaction usually occurs, which leads to destruction of thyroid cells and various thyroid disorders such as thyroiditis, hyperthyroidism, hypothyroidism, and other thyroid disorders. People with high thyroglobulin antibodies should lead a regular life and avoid drastic mood swings and exertion. It is recommended that thyroid function be rechecked regularly and treated under the guidance of a doctor.