The latest H. pylori quadruple therapy consists of a proton pump inhibitor such as omeprazole, a bismuth agent such as bismuth potassium citrate, and two antibiotics such as clarithromycin with amoxicillin, for a total of four drugs. The most common drugs used in the latest H. pylori quadruple therapy are two antibiotics such as clarithromycin in combination with amoxicillin, omeprazole, and bismuth potassium citrate, which are four drugs. The choice of drugs for quadruple therapy can be based on a comprehensive assessment of guidelines and local drug resistance, the patient’s own condition, and comorbidities. Not everyone uses the same drugs. Omeprazole is usually placed half an hour before meals, bismuth potassium citrate is also placed an hour before meals, clarithromycin and amoxicillin can be placed half an hour after meals, which need to be used for two weeks, and stopping the medication for a month can be reviewed in the hospital. Helicobacter pylori infection needs to be taken seriously, it is one of the biggest causes of stomach ulcers and stomach cancer, and is highly contagious, if a person in the family has Helicobacter pylori infection, it is best to recommend that the whole family collectively go to the hospital for examination. During the treatment period, you can eat separately from your family members to prevent contagion. At the same time, pay attention to dietary hygiene, avoid eating spicy and stimulating food. During the medication period, you must pay attention to strictly follow the doctor’s instructions, and after the treatment, you need to go to the hospital for a C14 blowing review to determine whether or not the H. pylori bacteria have been eradicated. If it has not been eradicated, the doctor needs to adjust the medication appropriately to continue the treatment.