A 24-hour urine protein quantification of 3.65g is called massive proteinuria, which is usually serious and requires prompt treatment. Normally most of the plasma proteins are reabsorbed by renal tubules, so there are only trace amounts of proteins in normal human urine. Urinary protein excretion rate > 150mg/24h is called proteinuria; if the urine protein content ≥ 3.5g/24h, it is called massive proteinuria. Massive proteinuria is common in nephrotic syndrome, tubular injury, and systemic lupus erythematosus, which are usually more severe, but the exact severity should be determined by the progress of the disease. Patients with 24-hour urine protein quantification of 3.65g should go to the hospital in time, under the guidance of professional physicians to clarify the cause of the disease and timely treatment.