Heart rate more than 50 times / min belongs to bradycardia, but does not belong to the contraindications of Sacubitril valsartan, therefore, if the indications of this drug are met, you can follow the doctor’s instructions to take Sacubitril valsartan for the treatment of the corresponding diseases. 1. The normal value of the heart rate of normal adults in a quiet state is 60~100 times/min, and the heart rate of more than 50 times/min is lower than the normal range, which belongs to bradycardia. It may be caused by autonomic dysfunction, beta receptor antagonist, severe hypoxia, hyperkalemia, hypothyroidism and other factors. 2. Sacubitril valsartan belongs to a combination of enkephalinase inhibitors and angiotensin receptor antagonists and is mainly used in the treatment of chronic heart failure with reduced ejection fraction. The use of this drug does not cause sinus bradycardia and is not contraindicated. Therefore, the heart rate of more than 50 times per minute, and meet the indications, if accompanied by chronic heart failure with reduced ejection fraction, can be taken in accordance with the doctor’s instructions. 3. Note that the drug components of allergy, hereditary or sudden angioedema is prohibited; in the process of using the drug need to pay attention to monitoring blood pressure, liver and kidney function and electrolytes, etc.; and pregnant women, breastfeeding women and other special groups, need to be under the guidance of a doctor to use the drug. The above medication should be used under the guidance of a doctor, avoid self-medication to avoid adverse consequences.