The child fever to eat cephalosporin for three days is not recommended to change azithromycin at will on their own, to have a clear application of azithromycin indications, under the guidance of the doctor to replace the drug. The pathogenic bacteria that cause the child’s fever infection are different, taking antibiotic drugs are not the same, eat cephalosporin three days effective case should not casually change the drug, eat cephalosporin three days no effect, to go to the hospital for examination, there is a clear application of azithromycin indications and then targeted medication. Cephalosporin belongs to the β-lactam antibiotics, the first generation, the second generation of cephalosporin for mild infections, for positive bacterial infections have a better antibacterial effect, the third generation, the fourth generation of cephalosporin is a broad-spectrum antibiotic, most of the bacteria have a good inhibitory effect. Azithromycin belongs to the class of macrolide antibiotics, mainly on gram-positive bacteria, some negative bacteria, chlamydia, mycoplasma and other atypical pathogens have antibacterial effect. The child fever body discomfort, it is recommended that under the guidance of the doctor targeted medication, parents do not blindly use drugs.