The official website of the General Administration of Food and Drug Administration (GFDA) released the “Announcement on Revision of the Instructions for Drugs Containing Codeine (No. 199 of 2016)” on January 4, indicating that it will be kicked out of the field of “children’s medicine” with immediate effect. Codeine is an alkaloid found in the opium poppy, as a coughing component, it inhibits the cough center in the human brain, and when it is metabolized from the body, part of it is metabolized to morphine, and the analgesic and sedative effect of morphine is also helpful in relieving cough. Based on the results of the adverse drug reaction assessment, the FDA decided to revise the codeine-containing drug instructions for [adverse reactions], [contraindications], [medication for children], and [medication for pregnant and lactating women]. In the “contraindications” added the following content: children under 12 years of age is prohibited; lactating women is prohibited. It is required that under the item “Children’s medication”, it should be stated that this product is prohibited for children under 12 years of age. This product is not recommended for children and adolescents aged 12 to 18 years with chronic respiratory disease. The main problem with codeine is that it is addictive. Large amounts can produce euphoria and hallucinations, and long-term use can lead to addiction. Withdrawal reactions occur with all long-term use, and pediatric patients are more sensitive. Physiologically, symptoms such as runny nose, sneezing and mental depression appear, and psychologically, they appear to actively seek out drugs, for example, like drug withdrawal, only to a lesser degree. If you are not in a special case of illness, follow medical advice and take the dose, the likelihood of addiction is almost 100 percent, and once addicted it is more difficult to quit. Parents should not buy cough medicine at will to take (nor is it safe to buy it in Hong Kong, oh, Pevs cough mixture has recently been listed as one of the varieties of Chinese medicine banned from sale and use in the United States and other countries because it is composed of a variety of drugs, including codeine, guaifenesin, paracetamol, ephedrine, etc.).