Most patients who have had a lumbar puncture will have pain for less than a week which is relatively normal. After a lumbar puncture, most patients will have significant pain relief within three days, a small number of patients may have pain for more than a week, but most patients will have significant pain relief or even disappearance in about two weeks. A very small number of patients may be left with long-term pain at the lumbar puncture site, which is often seen in the following situations: 1. It may be due to the difficulty of the lumbar puncture, resulting in local subcutaneous bleeding. This is often due to the narrowing of the lumbar space or the inability of the patient to achieve a lumbar puncture position that fully exposes the lumbar spine for his own reasons. 2. Local aseptic inflammation may exist. This is often due to repeated punctures, resulting in local inflammatory edema. 3. Local infection may occur. This is seen when the principle of aseptic operation is not followed during lumbar puncture, or when the wound is not protected in time after puncture, resulting in internal bacterial infection and back pain. 4. It may also be caused by leakage of cerebrospinal fluid. This is often seen when the patient does not follow the doctor’s instructions to stay strictly in bed after the lumbar puncture, which then results in this condition.