There is no such thing as the best thing to take to reduce swelling and dissipate nodules in thyroid nodules. If combined with changes in thyroid function, you can take propylthiouracil tablets, levothyroxine sodium tablets and other drugs as prescribed by the doctor to treat. 1. propylthiouracil tablets: propylthiouracil tablets have the effect of inhibiting the synthesis of thyroid hormones. Taking propylthiouracil tablets according to your doctor’s instructions can be effective in treating hyperthyroidism combined with thyroid nodules. 2. Levothyroxine sodium tablets: If it is simple goiter, or hypothyroidism combined with thyroid nodules, you can usually use levothyroxine sodium tablets according to the doctor’s instructions for treatment. Levothyroxine sodium tablets can play a role in replenishing thyroid hormones. Currently, the medication used to treat thyroid nodules needs to be decided according to the individual’s condition, so it is recommended that targeted treatment be carried out under the guidance of a doctor.