Chronic inflammation of gastric mucosa with mild atypical hyperplasia of glandular epithelium is a precancerous lesion of gastric cancer, which can be reversed to normal with proper treatment. Treatment includes general treatment, anti-Helicobacter pylori medication, vitamin supplementation and surgery. 1. General treatment: Don’t eat spicy and stimulating food, ensure balanced nutrition. Do not eat smoked or pickled food to reduce the stimulation of gastric mucosa. At the same time, keep a happy mood, moderate exercise, improve physical fitness. 2. Anti-Helicobacter pylori treatment: patients with atypical hyperplasia of the gastric mucosa are often accompanied by Helicobacter pylori infection, eradication of Helicobacter pylori is the prerequisite for other treatments, and can be used in the quadruple method, i.e., a proton pump inhibitor such as omeprazole + a bismuth such as bismuth pectin and two antibiotics such as amoxicillin and clarithromycin for eradication treatment. 3. Supplementation of multivitamins: Vitamin C and carotenoids have antioxidant effects, which can help reverse gastric mucosal atrophy and atypical hyperplasia to a certain extent. 4. Surgery:If the atypical hyperplasia develops to a severe degree, the abnormal tissues can be removed through surgery, and the removed tissues can also be used for pathological tissue diagnosis. Patients with chronic inflammation of the gastric mucosa with mild atypical hyperplasia of the adenoepithelium should go to the hospital in time, and under the guidance of the doctor to carry out regular treatment, which is expected to reverse the gastric mucosal lesions.