Lateral collateral ligament injury generally refers to the injury of the lateral collateral ligament of the knee, and patients need to follow the doctor’s instructions for non-surgical treatment, surgical treatment and so on. 1. Non-surgical treatment: If the lateral collateral ligament is mildly injured and does not affect the stability of the knee joint, it can be immobilized with a brace or plaster. Priority should be given to fixation with brace for 4~6 weeks. During the period of immobilization, attention needs to be paid to the prevention of deep vein thrombosis of the lower limbs. On this basis, if the patient’s pain is more severe, oral etoricoxib or celecoxib can be taken to relieve pain. 2. Surgery: If the patient’s condition is more serious and the lateral collateral ligament is completely ruptured, it will lead to the instability of anterolateral rotation of the knee joint, and if combined with cruciate ligament injury, the symptom will be more obvious, and even posterior rotational subluxation of the lateral condyle of the tibia will occur. Therefore, patients need timely surgical treatment to avoid sequelae. It is recommended that patients with lateral collateral knee ligament injury should strictly follow the doctor’s instructions for specific treatment and pay more attention to joint protection to avoid aggravation of the condition.