If the inability to open the mouth is caused by wisdom teeth pericoronitis, you can rinse locally and use antibiotics and other treatments; if it is caused by temporomandibular joint disorders, you can apply hot compresses, physiotherapy and other relief. 1. The inability to open the mouth can be caused by wisdom teeth pericoronitis, accompanied by gum swelling and pain around the wisdom teeth, etc., can be rinsed locally, the use of antibiotics under the guidance of the doctor, including cefuroxime, metronidazole, etc., and the presence of wisdom teeth blocking the wisdom teeth need to be carried out as early as possible after the control of inflammation, such as wisdom teeth extraction. 2. The inability to open the mouth can also be caused by temporomandibular joint disorder, usually should avoid biting hard objects, can be relieved by hot compresses, physiotherapy. If the symptoms of inability to open the mouth is obvious, go to the hospital in time to consult the examination, the use of the above drugs need to follow the doctor’s instructions.