The efficacy of painkillers varies depending on the type of disease and the individual’s tolerance of pain. Therefore, there is no fastest painkiller, you need to choose the most appropriate painkiller according to the type of disease, the severity of the disease, and at the same time for the cause of pain treatment, in order to effectively stop pain. Different types of pain should choose different painkillers. For example, headache, toothache, neuralgia, etc. can choose antipyretic and anti-inflammatory drugs such as diclofenac; trigeminal neuralgia, glossopharyngeal neuralgia can choose anti-epileptic drugs such as gabapentin, pregabalin, etc.; long-term pain with depression can choose amitriptyline and other antidepressants; post-traumatic pain can choose glucocorticoid hormone class, such as dexamethasone and so on. Painkillers should be analyzed according to the pain level and the factors that cause the pain, and the appropriate drugs should be chosen under the guidance of a medical professional instead of abusing painkillers.