There are three main categories of antihypertensive drugs that cause headache: 1. calcium channel antagonists, which are also the most common type of antihypertensive drugs that cause headache, short-acting drugs such as nifedipine and nifedipine tablets, long-acting nifedipine controlled-release tablets, nifedipine extended-release tablets, lercanidipine, amlodipine, etc. The more short-acting side effects of headache are more obvious, the more the side effects of strong antihypertensive ability of headache are also more obvious. 2. 3. α-blockers, which mainly cause postural hypotension and head hypoperfusion, cause headache.