Coughing episodes at night while sleeping can be caused by a variety of etiologic factors, such as physical and chemical stimuli, left heart failure, cough variant asthma, chronic bronchitis, respiratory infections and other causes. Depending on the cause, the treatment is as follows. 1. When the cough is irritated by physical or chemical factors, it should be kept away from the source of irritation. 2. When it is cough variant asthma, it is necessary to go to the hospital and follow the doctor’s instruction to dilate the bronchial tubes with bronchodilators such as budesonide and formoterol, and at the same time keep away from allergens. 3. If the cough is caused by left heart failure, we need to go to the hospital and use the cardiotonic treatment of Toxocarpine K, combined with furosemide and spironolactone diuretic to reduce the cardiac load and correct the heart failure. 4. Cough caused by chronic bronchitis need to pay attention to warmth, if necessary, take compound licorice tablets, aminobromine cough and phlegm treatment. 5. If the cough is caused by respiratory tract infection, antibiotics such as levofloxacin and cefoxitin should be used according to the condition to remove the cause of the cough. Frequent episodes of coughing at night may have other causes, need to go to the hospital for further consultation, clear diagnosis and symptomatic treatment, so as not to delay the condition.