Alprazole enteric-coated tablets alone cannot completely kill Helicobacter pylori, and need to be used in combination with other medications to eradicate H. pylori. Epprazole enteric-coated tablets are a chemical drug used to treat duodenal ulcer and reflux esophagitis in adults. Common adverse reactions include diarrhea, dizziness, headache, and elevated serum transaminases. The drug is contraindicated in those who are allergic to eplazole and other benzimidazoles and in those with hepatic and renal insufficiency. Helicobacter pylori, can be parasitized in the gastric mucosa tissue, infection can cause a series of gastrointestinal diseases, such as gastric ulcer, duodenal ulcer, atrophic gastritis and so on. Most infected people are asymptomatic, and their typical symptoms include abdominal pain, bloating, loss of appetite, acid reflux, nausea and so on. Eradication of H. pylori requires a combination of drugs, and its common methods include triple therapy and quadruple therapy. Triple therapy refers to one proton pump inhibitor (e.g., omeprazole, lansoprazole, etc.) plus two antibiotics (e.g., clarithromycin, amoxicillin, metronidazole, etc., with two selected according to the patient’s age, underlying disease, comorbidities and bacterial resistance). Quadruple therapy is the addition of a bismuth agent, such as colloidal bismuth pectin capsules, to triple therapy. For the treatment of Helicobacter pylori infection, it is recommended to go to a regular hospital and take reasonable medication under the guidance of a professional doctor, and not to take medication on your own, so as not to make a mistake.