Cyclosporine is used to prevent rejection after organ or bone marrow transplants, as well as for other immune-based diseases (e.g., psoriasis). The drug has numerous side effects, such as hypertension, edema, hematuria, headache, tinnitus, impaired liver function, and cardiac arrhythmias. Cyclosporine is a highly effective immunosuppressant that inhibits cell binding reactions and is commonly used for organ rejection after organ or bone marrow transplantation. It is also used in such immune system disorders as psoriasis, rheumatoid arthritis, atopic dermatitis, and nephrotic syndrome. It is also seen as an adjunctive treatment for leukopenia due to various primary diseases (hepatitis, atrophic gastritis, post radiation and chemotherapy). There are numerous side effects of cyclosporine, such as fever and night sweats (abnormal sweating after going to sleep, sweating stops after waking up), muscle pain, weakness, dry mouth, weight loss, hematuria, hypertension, chest pain, cardiac arrhythmia, hyperglycemia, itching of the skin, tremor, migraines, anxiety and depression, insomnia, somnolence, nausea and vomiting, hepatic impairment, upper gastrointestinal bleeding, tinnitus, arthralgia, and cough. Cyclosporine is contraindicated in allergy, pregnant women, breastfeeding, severe impairment of liver and kidney function, and used with caution in the elderly. It is forbidden to combine it with hydroxymetholone. The drug must be used under the supervision of a physician to avoid serious adverse consequences.