Ventricular wall thickening usually cannot be completely restored to its original state, but active treatment can slow the progression of the disease and can alleviate clinical symptoms and reduce complications and comorbidities. First of all, for ventricular wall thickening, it is important to identify the primary cause of the thickened myocardium, such as hypertensive heart disease, congenital heart disease, hypertrophic obstructive cardiomyopathy, or myocardial thickening due to heart valve disease or alcoholic cardiomyopathy, all of which can cause thickening of the ventricular wall. Depending on the patient, symptomatic treatment may include lowering blood pressure, quitting alcohol, quitting smoking, controlling diet, reducing sodium intake, and increasing exercise. At the same time, ventricular wall thickening can be treated with medications, such as ACEI drugs and beta-blockers, which can improve the function of the heart, improve the wall thickening and slow down the progression of the disease.