A fever in the middle of the night is a normal reaction of the body. A mild to moderate fever is a protective mechanism of the body and can help clear the body of bacteria and viruses. If a fever occurs in the middle of the night, the method of reducing the fever is decided according to the body temperature. A body temperature of 37.2℃-38℃ belongs to low fever, and it is only necessary to drink more plain water. If the body temperature is 38℃-39℃, it is a moderate fever. Besides drinking plain water, you can physically cool the body by wrapping an ice pack in a white towel or wiping the patient’s forehead, armpits, inner thighs, groin and neck with warm water to bring down the body temperature quickly. If the body temperature is greater than 39℃, the effect of oral antipyretic drugs and physical cooling is not effective, so you need to go to the hospital to find a professional doctor for diagnosis and treatment.