Blisters on hands without itching may be caused by blistering herpes, hand, foot and mouth disease, herpes sweating, chicken pox in the early stage and so on. 1. Vesicular herpes: caused by herpes virus infection, there will be blisters, papules, pain and other symptoms, some patients may not appear itchy symptoms. 2. Foot and mouth disease: caused by enterovirus infection, common in children, fever, rash or herpes in the mouth, hands, feet and other parts of the body, some patients may not be accompanied by itchy symptoms. 3. Herpes sweat: related to mental factors, local infection, allergy or irritation, etc., the hands of localized sweating, the formation of subcutaneous blisters, some patients may not be accompanied by itching symptoms. 4. Chickenpox early stage: by varicella zoster virus infection, or contact with chickenpox patients droplets, blisters, contaminated items, etc., the initial small blisters, low fever, malaise and other symptoms, some patients may not be accompanied by itching symptoms. Blisters on the hands without itching may have other reasons, it is recommended to go to the hospital in a timely manner, to clarify the cause of the disease, follow the doctor’s instructions standardized treatment.