Survival time after liver replacement at the age of 50 is determined by a number of factors, and the maximum survival time can be up to 30 years or more. Survival time after liver transplantation is determined by the patient’s own primary disease, personal constitution, the presence of related complications, rejection and postoperative recovery. If the patient has benign liver disease, early liver tumor with low malignancy or hepatitis cirrhosis, etc., and there is no complication, rejection or recurrence as mentioned above after transplantation, the 5-year survival rate can reach more than 80%, and the survival time may reach 20 years or even more than 30 years. On the contrary, if the patient is in the terminal stage of malignant tumors, tumors with higher degree of malignancy, or has developed metastasis, etc. before transplantation, and there are complications, severe rejection, or even recurrence and secondary metastasis after the operation, often the survival time will be greatly reduced, and some of them may only have 3-5 years, or even 1-2 years. Patients considering liver transplantation need to visit a hospital in time to be evaluated by a specialized physician based on the patient’s condition.