Physiological jaundice in newborns does not require treatment, while pathological jaundice is mainly treated by removing the cause of the disease, with medication and phototherapy, please follow the doctor’s instructions. Physiological jaundice in newborns usually needs no treatment, and the jaundice will subside on its own; pathological jaundice is mainly treated by removing the cause of the disease, and promoting bilirubin metabolism through medication and phototherapy, so as to achieve the purpose of removing jaundice. 1.Drug treatment: (1) The most common cause of increased bilirubin source is homoimmune hemolysis, i.e., hemolysis caused by incompatibility of blood groups between the mother and the child, which can be treated by intravenous injection of gammaglobulin. (2) If the liver’s ability to take up, bind and transport bilirubin is low, it will gradually improve within a week with the gradual maturation of liver enzymes; however, some children are congenitally deficient in the ability of liver enzymes to transport and bind bilirubin, and at this time, they can be treated with liver enzyme-inducing agents. (3) Glucose: supplement glucuronic acid raw materials, promote bilirubin excretion. (2) Phototherapy: if the child has no clear cause and the jaundice is mainly due to the increase of indirect bilirubin, phototherapy can be carried out, which can be treated with equipment such as phototherapy box, phototherapy lamps, LED lamps and phototherapy blankets, etc. During the treatment, attention should be paid to the appropriate supplementation of water, and the child’s eyes should be protected with eye shields. In conclusion, newborn jaundice should follow the doctor’s instructions standardized treatment, and pay attention to keep the child’s skin hygiene, clean, to avoid infection.