The drug of choice for the treatment of oral anaerobic infections is nitroimidazole drugs, such as metronidazole, tinidazole, ornidazole and so on. 1. Metronidazole: Metronidazole is the first generation of nitazole drugs, with anti-anaerobic bacteria, anti-trichomonas effect, this drug is more widely used. It can be used for the treatment of amebic liver abscess, pleural amebiasis, pouch worm disease, vaginal trichomoniasis and other diseases. It is commonly used in the treatment of anaerobic infections, so it can treat oral anaerobic infections. However, the side effects of this drug are relatively large and may cause great irritation to the stomach. 2. Tinidazole: Tinidazole is the 2nd generation of nitazole drugs, which can be used for various anaerobic infections, such as intra-abdominal infections, pelvic infections, sinusitis, sepsis and so on. For the basis of metronidazole has some improvement, less irritation to the stomach. Adverse reactions such as nausea, abdominal pain and loss of appetite may occur. 3. Ornidazole: Ornidazole is the 3rd generation of nitrazole drugs, further improved on the basis of the 1st and 2nd generation, reducing the stimulation of the stomach as well as some adverse reactions. It can be used to treat a variety of diseases caused by anaerobic infections, and can also be used for the prevention and treatment of anaerobic infections caused by various surgical procedures. These drugs should be used under medical supervision.