The treatment of oral buccal mucosal pemphigoid is generally a combination of local and systemic drug therapy, as follows. 1. Local drug treatment: use glucocorticoid preparation, such as tretinoin suspension in the buccal mucous membrane under the damage of infiltration injection treatment. 2. Systemic drug therapy: generally use aminophen sulfone for systemic drug therapy, aminophen sulfone can inhibit the release of neutrophil lysosomes and reduce the chemotaxis and adhesion of granulocytes. Azathioprine, methotrexate, thalidomide, sulfapyridine, sulfonamide and other drugs are also used in the treatment of mucocutaneous pemphigus. All of the above drugs should be used under the guidance of a doctor, and it is recommended to visit a hospital in time to receive regular treatment.