There is no such thing as which cold medicine works best, the cold medicine that combines symptomatic treatment and etiological treatment is the best choice. If the cold is caused by viral infection, you can choose to use anti-viral drugs, such as anti-viral oral liquid, Pudilan oral liquid, Blue Scutellaria oral liquid, Chai Yin granules, etc.. Drugs such as ribavirin, oseltamivir, and cytarabine can also be used appropriately and are relatively effective. If it is a secondary bacterial infection, antibiotics such as amoxicillin, cefuroxime, clindamycin, and levofloxacin can be used, and these drugs are more effective at this time. If the cold is caused by mycoplasma and chlamydia, macrolides are preferred, such as roxithromycin and azithromycin, which are more effective.