Red rash after leprosy vaccination may be caused by vaccine reaction, allergy, etc., which needs to be treated by hydration and medication. 1. Vaccine reaction: Due to individual differences, some patients may have the vaccine reaction of red rash after receiving leprosy vaccine, and some of them may also have low-grade fever, which will usually improve in three days, and physical cooling can be taken if the body temperature does not exceed 38.5℃, and oral antipyretic medication can be taken if the body temperature exceeds 38.5℃ as prescribed by the doctor. This situation needs to be appropriate to give the patient more water, to promote the metabolism of drugs. At the same time, need to pay more attention to rest, pay attention to skin cleaning, usually a few days after the symptoms will improve. 2. Allergy: The stimulation of certain drug components of leprosy vaccine may cause allergy in patients, and the allergic reaction of skin rash may appear. This situation can be treated with oral loratadine tablets, cetirizine tablets and other drugs under the guidance of the doctor, which can play a certain anti-allergic role. In the case of red rash caused by leprosy vaccine, it is necessary to actively listen to the professional doctor’s advice to deal with the situation, and the medication should be taken in accordance with the doctor’s advice, and should not be used on its own.