Rheumatoid arthritis knee pain treatment is mainly drug therapy, commonly used types of drugs include anti-infective drugs and anti-rheumatic drugs. 1. Anti-infective treatment: rheumatoid arthritis is a reactive joint inflammation that occurs after the patient is infected with group A beta-hemolytic streptococcus, which can cause knee pain, so anti-infective drugs such as benzylpenicillin can be used to remove the infected foci, and if the patient is allergic to penicillins, erythromycin, lincomycin, roxithromycin, cephalosporins and other medications can be used to treat the disease. 2. Anti-rheumatic treatment: commonly used drugs in anti-rheumatic treatment include aspirin, ibuprofen and other non-steroidal anti-inflammatory drugs and hydrocortisone, prednisone and other glucocorticoids. It is recommended that patients go to the rheumatology and immunology department of regular hospitals for detailed consultation and follow the doctor’s instructions for medication to avoid delaying the condition.