Higher white blood cells can be seen in physiologic or pathologic highs. Physiological high leukocytes generally do not require treatment, while pathological high leukocytes are commonly seen in infections, blood system diseases, etc. Treatment includes medication, surgery, radiation therapy, and so on. 1. Physiological increase: generally seen after activity and eating, exercise, newborn, pain, emotional excitement, pregnancy, labor and delivery, etc., generally do not need treatment. 2. Pathologic increase: (1) Infectious diseases: such as pneumonia, tonsillitis, appendicitis caused by streptococcus, pneumococcus, staphylococcus aureus, etc. Lamivudine, cephalosporin, gentamicin, etc. can be given to anti-infective treatment. (2) Hematological diseases: for example, acute leukemia can be treated with chemotherapy (e.g. vincristine, hypertriglyceridin, zorubicin, etc.), chronic granulocytic leukemia can be treated with molecular targeting therapy (e.g. nilotinib, imatinib mesylate, etc.), and non-Hodgkin’s lymphoma can be treated with immunotherapy (e.g. rituximab), surgical treatment (bone marrow transplantation), and radiation therapy. In addition to the above, high white blood cells are also seen in tissue injury, acute blood loss, acute poisoning, etc., which can be given targeted treatment, such as acute poisoning can be carried out timely gastric lavage to induce vomiting. It is recommended to go to the hospital in time, complete the examination to clarify the cause of the disease, and then give targeted treatment. The above medication should be used under the guidance of a doctor or pharmacist, avoid self-medication.