The pathogenesis of osteosarcoma is currently unclear, and clinically it is usually thought to be related to chemical substances, viral infections, and radioactive substances. Clinically, it is currently believed that heredity or various chemical, radioactive, viral and other pathogenic factors will induce this disease, such as hereditary retinoblastoma, zinc beryllium silicate, long-term exposure to ionizing radiation, SV40 viral infection and so on. In addition, certain benign bone diseases can be malignant into osteosarcoma, such as Paget’s disease and osteochondroma. A variety of disease-causing factors act on normal cells, causing activation of proto-oncogenes, which are unable to repair damaged DNA in the process of replication and transcription, thus affecting the cell cycle and causing unlimited proliferation of cancer cells, leading to osteosarcoma.