Splenomegaly, with Helicobacter pylori infection stool bleeding may be cirrhosis caused by gastrointestinal bleeding, peptic ulcer, hematologic disorders and so on. 1. Cirrhosis causing peptic bleeding: Cirrhosis can lead to rupture and bleeding of esophagogastric fundus varices, or complication of hepatogenic peptic ulcer leading to rupture and bleeding of peptic mucous membrane; meanwhile, cirrhosis can be accompanied by enlarged spleen, combined with Helicobacter pylori infection, and bleeding in stool. 2. Peptic ulcer: peptic ulcer is often associated with Helicobacter pylori infection, which can be complicated by peptic bleeding and may be accompanied by splenomegaly. 3. Hematologic disorders: diseases such as leukemia, thrombocytopenic purpura, and multiple myeloma can have low platelets leading to gastrointestinal bleeding, often with splenomegaly. Splenomegaly, accompanied by Helicobacter pylori infection stool bleeding patients should be timely to the hospital, clear reasons, under the guidance of the doctor in a timely manner according to the cause of systemic treatment.