Sigmoid colon kras mutation means that the kras gene is abnormal and there is permanent activation of the gene, which cannot produce kras protein normally, making the cell proliferation out of control and leading to the appearance of cancer. For kras mutant sigmoid colon cancer, the treatment plan mainly depends on the stage of colon cancer and the patient’s physical condition. Surgery is preferred, especially when there is no lymph node metastasis or distant metastasis, and the patient’s physical condition is very good and can tolerate the surgery. After surgery, postoperative adjuvant therapy, chemotherapy or radiotherapy will be done according to the pathological stage. Sigmoid colon kras mutation means that cetuximab cannot be used. Therefore, kras colon cancer still needs comprehensive treatment according to the stage of colon cancer. Sigmoid colon kras mutation, it is recommended to seek timely medical treatment, diagnosis and treatment under the guidance of physicians, regular follow-up colonoscopy and other treatments, and be alert to cancerous changes, so as not to delay the condition.