Closure needling is also called closure therapy. It is a treatment that provides pain relief, promotes inflammation and tissue repair by injecting medication into localized lesions. Closure therapy is suitable for localized lesions such as muscle ligament stopping point pain, tenosynovitis, etc. It can be used for acute or chronic pain. However, it is not suitable for large widespread pain. Commonly used closure methods include localized pressure point closure, tendon sheath closure, bursa closure, joint cavity closure and so on. Closure of commonly used drugs is composed of anesthetic and glucocorticoid drugs mixed in a certain proportion. Commonly used anesthetics are procaine, lidocaine, etc., glucocorticoid drugs such as prednisolone acetate, compound betamethasone, etc.. Closed for tuberculosis, septic arthritis, osteomyelitis, bone tumors and other prohibited. Patients with poor physical condition or severe cardiovascular disease should be used with caution after evaluation. Sequestration is an invasive operation, and it is recommended that patients go to regular hospitals and undergo sequestration according to aseptic operation norms.