High immunoglobulin in patients with dry syndrome is caused by dry syndrome disease itself, which needs to be treated with medication for dry syndrome. Dry syndrome is caused by the dysfunction of the immune system in the patient’s body, the formation of autoantibodies and lead to autoimmune reaction, and immunoglobulin is involved in the immune reaction, so this kind of disease patients often have high immunoglobulin, and this situation needs to be treated for dry syndrome. The treatment of dry syndrome is based on medication, and commonly used medications include non-steroidal anti-inflammatory drugs such as diclofenac, immunosuppressive drugs such as methotrexate, glucocorticosteroids such as prednisone, biologics such as rituximab, and antimalarial drugs such as hydroxychloroquine. A specific treatment plan should be formulated according to the patient’s condition, individual constitution and other factors. Although the disease cannot be cured, its progression can be effectively controlled through standardized treatment. Drugs should be used under the guidance of a physician, and it is recommended that patients with dry syndrome go to the rheumatology and immunology department of a regular hospital for a detailed consultation and treatment in accordance with the doctor’s instructions.