Creatinine 145μmol/L can be seen in physiological reasons such as strenuous exercise, muscular athletes, etc., generally not serious, pay attention to rest, regular review can be; can also be seen in pathologic conditions such as acute and chronic renal failure, which is a serious situation, need to be for specific causes of targeted treatment. Physiological conditions, such as strenuous exercise, muscular athletes, eating a lot of meat, etc., are generally not serious and do not require treatment, pay attention to rest, light diet, and regular review can be. Pathological conditions such as acute and chronic renal failure, common causes such as diarrhea, gastrointestinal bleeding, drug renal injury, urinary tract obstruction and so on can lead to acute renal failure; glomerulonephritis, hypertensive nephropathy, diabetic nephropathy and so on can lead to chronic renal failure, no matter what the cause is, it is more serious, and need to be targeted at the cause of the specific treatment. If the blood creatinine rises, it is recommended to go to regular hospitals in time to find out the cause and standardize the treatment under the guidance of physicians.